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NCBI Bookshelf. Phyu Thin Naing ; Utkarsh Acharya. Hairy cell leukemia HCL is a relatively lookihg chronic B-cell malignancy that involves the bone marrow, spleen, and peripheral blood. The complete blood count may reveal pancytopenia including monocytopenia.

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It is important to note that these patients will be immunosuppressed for many months following therapy, and attention to possible infectious complications is critical. History and Physical Affected patients often have non-specific symptoms including fatigue and lloking, as well as symptoms related to cytopenias and splenomegaly.

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